Enclomiphene Patient Education Guide

  • Enclomiphene is a selective estrogen receptor modulator (SERM) that influences hormonal signaling by interacting with estrogen receptors in the hypothalamic–pituitary–gonadal axis.

    Enclomiphene is an isomer of clomiphene and works by encouraging the body’s own hormone production rather than supplying external hormones.

  • In women, enclomiphene may be used in carefully selected cases to support endogenous hormone signaling when estrogen feedback mechanisms are contributing to hormonal imbalance.

    Its use in women is provider-directed and individualized, often considered in specific clinical contexts rather than routine hormone replacement.

  • Enclomiphene may:

    • Influence estrogen feedback signaling in the brain

    • Encourage natural gonadotropin release

    • Support downstream production of ovarian hormones

    • Promote hormonal signaling balance rather than hormone substitution

    Its mechanism focuses on signaling pathways, not direct hormone delivery.

  • Hormonal regulation depends on precise feedback between the brain and ovaries. Disruptions in this signaling can affect cycle regularity and hormone balance.

    Enclomiphene may support women who:

    • Experience hormonal imbalance related to signaling dysfunction

    • Have suppressed endogenous hormone production

    • Are seeking non-replacement approaches under provider supervision

    • Require carefully guided endocrine support based on labs and symptoms

    Because hormonal needs vary widely, suitability is determined through provider evaluation and monitoring.

  • Can:

    • Support endogenous hormone signaling pathways

    • Encourage the body’s own hormone production in select cases

    Cannot:

    • Replace estrogen or progesterone therapy when indicated

    • Be used without clinical oversight

  • Enclomiphene use in women requires thorough provider evaluation, including review of hormonal labs, reproductive history, and clinical goals. It is not appropriate for all individuals.

    Monitoring may be required throughout use.

  • Enclomiphene is offered only following licensed provider review. It is not intended to diagnose, treat, cure, or prevent disease, and its use is individualized based on clinical judgment.